Vascular eds heart problems. Question: October is Vascular Ehlers-Danlos Syndrome .

Vascular eds heart problems Because vascular Ehlers-Danlos syndrome can have serious potential complications in pregnancy, you may want to talk to a genetic counselor before starting a family. Because sexual performance is made possible by small blood vessels, dysfunction may serve as a warning of these potentially bigger problems. Ehlers-Danlos Syndrome (EDS) Ehlers-Danlos syndrome (EDS) is a genetic condition that weakens your body’s connective tissue. The prevalence and significance of such abnormalities in patients with classical (cEDS) or hypermobile EDS (hEDS) remain unclear. During a period of seven years, a diagnosis of Ehlers-Danlos syndrome was made in 44 patients. Other forms of EDS such as vascular EDS are associated with joint hypermobility and serious cardiovascular complications including arterial aneurysms Vascular Ehlers-Danlos syndrome (VEDS) is a genetic condition that makes the arteries and hollow organs prone to tear, due to a mutation in the COL3A1 gene. Methods: We identified 532 pediatric patients with potential EDS evaluated at our Feb 1, 2014 · Vascular Ehlers–Danlos syndrome (vEDS) is an autosomal dominant disease that affects the arteries, bowels, uterus, and skin. Patients with cvEDS have progressive weakening of the heart valves and may have problems such as high blood pressure. Learn about the symptoms, diagnosis, and treatment. Vascular Ehlers-Danlos Syndrome is an Autosomal Dominant disease, following Autosomal Dominant inheritance. Apr 14, 2022 · Vascular Ehlers-Danlos is a more severe form of the disorder that affects blood vessels. This means that you only need to have one abnormal copy of the responsible gene (from either parent) to have the disease. What is the cause of cvEDS? cvEDS is caused by variations in a person’s genes. Rare Disease 360, in partnership with The Marfan Foundation, spoke with Hal Dietz, MD, a cardiologist and geneticist at Johns Hopkins University, about the importance of educating primary care physicians and emergency department physicians on the signs and symptoms of VEDS. Affected individuals can have spontaneous rupture of hollow organs, such as the bowels or gravid uterus, along with arterial dissections and ruptures that lead to premature death. Patients with these defects frequently present at a young age with spontaneous arterial complications involving the Vascular Ehlers-Danlos syndrome (VEDS) is one of the different subtypes of Ehlers-Danlos syndrome (EDS). “Our study sheds light on the subtle [heart muscle] abnormalities in vEDS,” the researchers wrote. Managing and monitoring What is cvEDS? cvEDS is an incredibly rare type of EDS which causes severe heart valve problems, atrophic scarring, hyperextensibility of the skin and joint hypermobility. [3] Complications may include aortic dissection, joint dislocations, scoliosis, chronic pain, or early osteoarthritis. A person can have vascular EDS for one of two reasons: Every gene in the body has two copies—one inherited from each parent. What Is Vascular Ehlers-Danlos Syndrome? Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited con-nective tissue disorders. 27, 2022, by Marisa Wexler, MS Fact-checked by José Lopes, PhD Ehlers-Danlos syndrome (EDS) is the name given to a group of related genetic diseases characterized by weakness in the connective tissue that makes up joints and holds tissues together. Ehlers-Danlos syndrome (EDS) is a connective tissue disorder resulting in joint hypermobility, skin extensibility, and tissue fragility. This is the material that provides strength and structure to: Skin Bone Blood vessels Internal organs The variant collagen leads to the symptoms associated with EDS. Vascular EDS is not as common as hypermobile EDS, but important to recognize because of vascular complications. One of the primary cardiovascular concerns in individuals with EDS, particularly the vascular subtype (vEDS), is the fragility of blood vessel walls. Ehlers-Danlos and Aortic Dissection Risks Ehlers-Danlos syndrome (EDS) is a group of genetic connective tissue disorders. What are the symptoms found in those affected by Vascular Ehlers-Danlos syndrome, or VEDS? The following are symptoms found in people with Vascular Ehlers-Danlos Syndrome (VEDS): Cardiovascular and arterial characteristics There is no increased risk of valvular or structural cardiac defects. This rare condition is caused by pathogenic variants in the COL3A1 gene and affects the digestive system, the uterus, the skin, and the Treatment and management recommendations for those with Vascular Ehlers-Danlos Syndrome, or VEDS, including circumstances to avoid and medications. There were two cases of atrial septal defect, ooe case of aortic incompetence, one case of left ventricular papiDary . Our approach to Vascular Ehlers-Danlos syndrome (VEDS) Children with vascular Ehlers-Danlos syndrome often struggle with heart problems. Apr 10, 2022 · Vascular EDS causes people to bruise more easily. In particular they may suffer from problems related to heart rhythm and blood pressure. Understanding this connection can make a big difference in how we approach treatment and daily management. Individuals with this condition may experience heart abnormalities and vascular complications, which can have significant implications for their cardiovascular health. Nov 6, 2024 · Ehlers-Danlos syndrome (EDS) is a group of inherited disorders marked by extremely loose joints, very stretchy (hyperelastic) skin that bruises easily, and easily damaged blood vessels. Data on sex differences in peripheral vascular disease are ill defined, and there is a need to report and understand those sex-related differences to mitigate adverse outcomes related Apr 15, 2019 · Of all hereditary connective tissue diseases, vascular Ehlers-Danlos Syndrome (vEDS) is pre-eminently the most feared—mainly due to the unpredictability in the occurrence of potentially serious/fatal vascular events such as arterial dissection or rupture. Managing pregnancy in Causes There are at least 13 types of EDS. A variety of gene changes (mutations) cause problems with collagen. Some rare types of EDS are characterised by cardiovascular problems - the vascular type carries a risk of arterial rupture at a young age, and in cardiac-valvular EDS there are severe progressive problems of the aortic and mitral valves. The condition is characterized by aneurysms (a bulge in an artery), rupture of the bowel, and rupture of the womb during pregnancy. Congenital heart defects included bicuspid aortic valve (two), pulmonary valvular stenosis (one), ventricular septal defect (two), and an atrial septal defect (one). High blood pressure (hypertension) and problems with heart valves (such as mitral valve prolapse) happen very frequently. cvEDS is caused by variations in gene COL1A2. Jan 5, 2024 · Marfan, Loeys-Dietz, Ehlers-Danlos syndrome and the more severe Vascular Ehlers-Danlos syndrome, and other connective tissue disorders are congenital, meaning they are present from birth. The pulmonary issues of this syndrome are widely under-researched despite the significant impact these symptoms have on the EDS Jun 26, 2024 · Background Vascular Ehlers-Danlos syndrome (vEDS) is a hereditary connective tissue disorder associated with an elevated risk of vascular, uterine and digestive complications. [1] These may be noticed at birth or in early childhood. The symptoms listed here may not affect everyone with cvEDS, and people with cvEDS may have other symptoms that are not listed on this page. Question: October is Vascular Ehlers-Danlos Syndrome Jun 19, 2020 · It’s also been associated with disease in the aorta. Classical EDS (cEDS) and vascular EDS (vEDS) are much rarer than hEDS. Several types of EDS have only been reported in a few affected families. One patient was excluded due to complex congenital heart disease, and two were excluded due to lack of images. This recognition was gained through case reports, descriptions of the Vascular Ehlers-Danlos syndrome (VEDS) is a genetic condition that is caused by a change (mutation) in the gene for collagen type 3 (the COL3A1 gene). In some cases, vascular Ehlers-Danlos can weaken the walls of the large intestine or uterus, too. Early diagnosis and medical management is key to slowing the development of a weakened aorta. What Causes Vascular Ehlers-Danlos Syndrome? About half of people with Vascular Ehlers-Danlos syndrome inherited the COL3A1 mutation from an affected parent. Disease Information Summary Vascular Ehlers-Danlos syndrome is an inherited connective tissue disorder that is caused by defects in a protein called collagen. It is generally considered the most severe form of Ehlers-Danlos syndrome (EDS). Ehlers-Danlos Syndrome (EDS) includes various connective tissue disorders, each with distinct features Vascular Ehlers–Danlos syndrome (vEDS) is a rare autosomal dominant connective tissue disease resulting from pathogenic variants in the collagen type III alpha 1 chain (COL3A1) gene, encoding type III procollagen. In the absence of guidelines, many experts Significant advancements in genetic testing have contributed to understanding of the cause, management, and treatment of vascular connective tissue disorders, which include Ehlers-Danlos syndrome, Marfan syndrome, and Loeys-Dietz syndrome. We would like to show you a description here but the site won’t allow us. In this case report, we describe the first reported case of Aug 25, 2022 · A more severe form of the disorder, called vascular Ehlers-Danlos syndrome, can cause the walls of your blood vessels, intestines or uterus to rupture. What are the common symptoms of Vascular Ehlers-Danlos Syndrome? The common symptoms of Vascular Ehlers-Danlos Syndrome (VEDS) include thin, translucent skin that is prone to bruising and tearing, easily visible veins, arterial and organ ruptures, joint dislocations, abdominal and chest pain, and a collapsed lung. During pregnancy, women with vascular Ehlers-Danlos syndrome may experience rupture of the uterus. The clinical manifestations are varied, being the most obvious skin hypermotility and Apr 2, 2020 · Cardiac–valvular and vascular Ehlers–Danlos syndrome (EDS) have significant cardiovascular issues. Nov 14, 2000 · Any review of the critical developments that fostered the birth of cardiovascular genetics must acknowledge the enormous contributions made by clinicians, patients, and families. The Ehlers-Danlos Syndromes (EDS) are genetic connective tissue disorders that are currently categorized into 14 subtypes. Jun 9, 2020 · Cardiac–valvular and vascular Ehlers–Danlos syndrome (EDS) have significant cardiovascular issues. Vascular EDS: This is the most severe type, and it affects the heart and other organs. PMR is rare, life-threatening event in which the rupture of the heart’s papillary muscles leads to acute mitral valve regurgitation — a condition in which the mitral valve on the left side of Sep 13, 2022 · The vascular type of Ehlers-Danlos syndrome is predisposed to blood vessel and bowel rupture. These valves control how the blood flows out of the heart with every heartbeat. Common signs of dysautonomia include: Tachycardia (fast heart rate) Hypotension (low blood pressure) Dizziness/lightheadedness Gastrointestinal dysmotility (problems moving food through the digestive system A severe subset of this genetic disease, known as vascular Ehlers-Danlos syndrome, can weaken the aorta, which in turn can lead to aneurysm and life-threatening rupture. Conclusion Management of vascular Ehlers-Danlos syndrome requires a multidisciplinary care team, which should provide: Molecular diagnosis and family screening Emergency care Follow-up as required Arterial monitoring Apr 15, 2025 · Here, I focus predominantly on vascular EDS (EDSv) by discussing its prevalence, the specific inheritance pattern, associated genes and affected proteins, features that characterize it, how it can affect the cardiovascular system, and ultimately, the treatment of its symptoms. Nov 20, 2019 · How are erectile dysfunction (ED) and heart problems linked? Our expert explains. Dec 18, 2023 · Ehlers-Danlos syndrome (EDS) affects the body's connective tissues. Oct 8, 2024 · Ehlers Danlos syndrome (EDS) is a rare condition affecting connective tissue that supports skin, joints, blood vessels, and internal organs. Introduction: Mitral valve prolapse and aortic root dilatation are reported in association with hypermobile Ehlers-Danlos syndrome (hEDS), but the full phenotypic spectrum of cardiovascular complications in this condition has not been studied in the aftermath of updated nosology and diagnostic criteria. Nov 12, 2024 · I've been getting so many questions from patients and colleagues about how Ehlers-Danlos Syndromes (EDS) affects the heart and nervous system, so I wanted to share some key takeaways from a recent study that dives into this very topic. Apr 2, 2020 · Methods: We identified 532 pediatric patients with potential EDS evaluated at our institution from January 2014 through April 2019 by retrospective chart review. Ehlers-Danlos syndrome (EDS) affects the connective tissues that support our joints, muscles, skin and even organs. Learn about the link and treatments here. A variety of gene variations cause problems with collagen. Characterized by articular hypermobility, skin exten-sibility and tissue fragility, individuals with EDS have a defect in their connec-tive tissue. In some forms of the Mar 11, 2025 · Sex differences in the risk factors, diagnosis, treatment, and outcomes of patients with cardiovascular disease have been well described; however, the bulk of the literature has focused on heart disease in women. This can help manage artery problems better. Introduction The Ehlers-Danlos Syndromes (EDS) give rise to a spectrum of features affecting the mouth that may lessen quality of life. Dysautonomia, also known as autonomic dysfunction, is a group of disorders that affect the autonomic nervous system (ANS). Find out what causes this condition and how it's treated. cEDS affects roughly 1 in 20,000-40,000 people. Symptoms of each subtype overlap, with some distinct manifestations. Other forms include the classic and vascular forms. Oct 28, 2019 · Cardiac-valvular Ehlers-Danlos syndrome is characterized by problems in the heart valves, which accompany the more common symptoms of EDS. Navigate the body map to learn more about the condition. Children with vascular Ehlers-Danlos syndrome often struggle with heart problems. In some forms of the syndrome, the rupture of internal organs or abnormal heart valves can occur. These can include joint hypermobility, stretchy skin and tissue fragility. Ninety-five patients (12 cEDS and 83 hEDS patients) met 2017 EDS diagnostic criteria and had an echocardiogram. \n\nOther types of Ehlers-Danlos syndrome have additional signs and symptoms. Learn about Ehlers-Danlos syndrome, find a doctor, complications, outcomes, recovery and follow-up care for Ehlers-Danlos syndrome. Some rare types of EDS are characterised by cardiovascular problems – the vascular type carries a risk of arterial rupture at a young age, and in cardiac-valvular EDS there are severe progressive problems of the aortic and mitral valves. Individuals with VEDS may also experience chronic pain, fatigue, and muscle October is Vascular Ehlers-Danlos Syndrome (VEDS) Action Month. However once the diagnosis is known it can be used to guide medical care in an emergency situation. There is an increased risk of coronary artery dissection, and as a result, myocardial infarction (heart How to Use: Explore the features of cvEDS by selecting different body parts from the menu. It is caused by a gene mutation affecting a major protein, which causes weakness in vessel walls and hollow organs. Apr 5, 2018 · Ehlers-Danlos syndrome (EDS) is a hereditary disease of disordered collagen matrix formation leading to skin laxity, joint hypermobility, and, in the worst case, fragility of blood vessels or organs, leading to rupture and premature death. The apparent high prevalence of cardiovascular abnormalities in hospitalized patients with types I and III Ehlers-Danlos syndrome necessitates a careful cardiovascular evaluation. At Stanford Medicine Children’s Health, we collaborate closely with our renowned heart specialists at Betty Irene Moore Children’s Heart Center. 6, 7 Incidence of these disorders were previously reported between 6% and 21%, 8, 9 Vascular Ehlers-Danlos Syndrome (vEDS) is a rare and severe subtype of Ehlers-Danlos Syndrome (EDS), a group of inherited disorders affecting connective tissue. vEDS affects about 1 in 100,000-200,000 people. [1][4] The existing Ehlers-Danlos Syndrome (EDS) is one of the most complex conditions affecting the human body because EDS impacts almost every system. Hypermobile EDS is the most common type (90% of cases). Mitral valve prolapse and aortic root dilatation are reported in association with hypermobile Ehlers–Danlos syndrome (hEDS), but the full phenotypic spectrum of cardiovascular complications in this condition has not been studied in the aftermath of updated nosology and diagnostic criteria. It can weaken the aorta, which is the large artery that carries blood away from your heart, as well as the arteries in the neck and abdomen. These disorders affect the body’s collagen. Ehlers-Danlos Syndrome with Cardiac Valve Involvement Cardiac-Valvular Ehlers-Danlos Syndrome (CVEDS) is an extremely rare connective tissue disorder that impacts the heart and its valves, potentially causing serious cardiac complications and valve-related problems due to genetic mutation. Oct 30, 2019 · Vascular EDS Last updated Jan. It’s important to know the difference between common symptoms and those in Ehlers Danlos Jul 14, 2025 · Lucian Durham, MD, PHD Vascular Ehlers-Danlos Syndrome Vascular EDS is one of 13 types of EDS, which affects the connective tissue. Children with vascular EDS may also have short stature, recessed gums, and a low amount of fat under their skin. Mar 18, 2024 · 1 Introduction Hypermobile Ehlers-Danlos syndrome (hEDS) and hypermobility spectrum disorders (HSD) are common connective tissue disorders that have a strong genetic basis from family history yet no identified genetic variant/s (1, 2). Aug 12, 2024 · Ehlers- Danlos syndrome and postural orthostatic tachycardia syndrome (POTS) often occur together. Nov 11, 2019 · Introduction: The cardiac-valvular and vascular subtypes of Ehlers-Danlos Syndrome (EDS) have significant cardiovascular issues, specifically aortic or mitral valve dysfunction, and arterial dilation and dissection. Vascular Ehlers-Danlos Syndrome Vascular Ehlers-Danlos syndrome (VEDS) is a condition that is quite variable. It can be used to identify heart disease and other problems involving heart function and vascular concerns. It’s also more common for people with this condition to develop varicose veins at earlier ages. The autonomic nervous system controls important functions like heart rate and blood pressure. Ehlers–Danlos syndromes (EDS) are a group of 13 genetic connective tissue disorders. This fragility results from defective collagen, a vital structural protein that provides tensile strength to blood vessels. Cardiovascular problems Some rare types of EDS are characterised by cardiovascular problems - the vascular type carries a risk of arterial rupture at a young age, and in cardiac-valvular EDS there are severe progressive problems of the aortic and mitral valves. This article provides a review of the oral and dental aspects of […] Sep 11, 2025 · Ehlers-Danlos syndrome is a group of genetic disorders that affect the connective tissues and cause symptoms such as stretchy skin and loose joints. The review was conducted Feb 4, 2017 · The committee on Cardiovascular Dysautonomia of the International Ehlers–Danlos Syndrome Consortium met by teleconference or through electronic correspondence throughout 2015 and 2016 to discuss the associations of cardiovascular autonomic dysfunction with hEDS and its assessment and management. Learn More. Written by a GP. [7] Symptoms often include loose joints, joint pain, stretchy, velvety skin, and abnormal scar formation. Sep 8, 2023 · Vascular EDS, a form of the disease affecting blood vessels and internal organs, is typically considered the most severe form of EDS, as it’s associated with an increased risk of serious bleeding. Recognizing Symptoms of Artery Dissection Knowing the signs of artery dissection is key for quick medical help. Feb 23, 2016 · Vascular Ehlers-Danlos syndrome (EDS) is a relatively rare genetic syndrome that occurs owing to disorders in the metabolism of fibrillary collagen. We follow patients with diagnoses of VEDS in our Connective Tissue Disorder Program here at Lurie Children’s. It commonly affects your skin and joints. People are often diagnosed when they have easy and frequent bruising that is not explained by other causes, spontaneous bowel perforations or arterial tears, or because other family members are afected. We reviewed Feb 1, 2014 · Vascular Ehlers–Danlos syndrome (vEDS) is an autosomal dominant disease that affects the arteries, bowels, uterus, and skin. It’s important to know how EDS affects the heart. Problems with this system (autonomic dysfunction) contribute to a worse quality of life in the hypermobile type of Ehlers-Danlos syndrome (hEDS). The cases were studied with particular reference to involvement of the cardiovascular system. The vascular subtype, while rare, can be especially severe and life threatening. The prevalence and significance of such abnormalities in classical (cEDS) or hypermobile EDS (hEDS) remain unclear. Please note that cvEDS affects each person differently. It is inherited in an autosomal dominant way which means that if a person has vEDS there is a 50% […] Many children with vascular EDS do not present with any medical problems and most people with vascular EDS are diagnosed as adults. Read about symptoms, diagnosis, management, genetic factors and more. By pursuing the most innovative research, educating the medical community, general public and affected individuals, and providing support to patients, families, and caregivers, we can charge forward and improve the outcomes for those living with VEDS. Individuals with hypermobile Ehlers-Danlos syndrome (hEDS) can suffer with symptoms that appear to be related to abnormal function of the ANS; the term autonomic dysfunction is used. Kyphoscoliosis EDS: Children with this type typically have severe EDS at birth, delayed motor development, and progressive kyphosis and scoliosis. Similar problems are found in fibromyalgia and chronic fatigue syndrome. Many people with EDS or HSD also have a type of dysautonomia. People with vEDS will be at a 50% Learn about Vascular Ehlers-Danlos Syndrome (vEDS) and it's signs and symptoms. Individuals with certain types of EDS experience vascular complications, such as arterial dissection and aneurysm. There’s no cure, but your healthcare provider will help you find treatments to manage the symptoms and prevent dangerous complications. Oct 31, 2019 · Routine heart tests and echocardiography — a non-invasive test that uses sound waves to create moving pictures of the heart — may not be necessary for patients with hypermobile Ehlers-Danlos syndrome (hEDS) who have no family history of heart problems, a small study reports. This knowledge An echocardiogram is a type of ultrasound that uses sound waves to show the radiologist images of the heart and blood vessels of the heart. How is cvEDS diagnosed? When diagnosing cvEDS a list of common and relevant signs and symptoms of What other names do people use for vascular Ehlers-Danlos syndrome? Vascular Ehlers-Danlos syndrome is also referred to as vEDS, Ehlers-Danlos syndrome type IV, Sack-Barabas syndrome, and the arterial form of Ehlers-Danlos syndrome. Typical signs and symptoms include fast heart rate, low blood pressure, digestive system problems, disturbed bladder function and sweating regulation Sep 7, 2025 · Ehlers-Danlos syndrome is a group of genetic connective tissue disorders classified in 13 types. Ehlers Danlos Syndrome & Artery Dissection Risks These studies show we need to watch EDS patients closely and take steps to lower their heart risks. These defects affect the soft connective tissues resulting in abnormalities in the skin, joints, hollow organs, and blood vessels. This meta-analysis assesses the prevalence of vascular complications in among patients with EDS. The majority of EDS cases are either hypermobile, vascular, or classic. Jul 15, 2020 · Cardiac-valvular EDS (cvEDS) affects the connective tissue that forms the heart valves. Additionally, routine dental care has the potential to be compromised as a consequence of some of the systemic features of the disease. Patients with vEDS present with The VEDS Movement mission is to save lives and improve the quality of life of individuals with Vascular Ehlers-Danlos Syndrome (VEDS). Purpose: Cardiac-valvular and vascular Ehlers-Danlos syndrome (EDS) have significant cardiovascular issues. Jan 10, 2022 · Potentially serious cardiovascular manifestations are well cited in the vascular, classical, and cardiac-valvular forms of EDS. Apr 9, 2024 · Ehlers-Danlos syndrome - a genetic disorder that causes unusual flexibility and thin skin, is known to weaken the connective tissues, leading to weak joints, blood vessels and organs. We report the prevalence of cardiac abnormalities in patients with cEDS and hEDS. Vascular Ehlers Danlos syndrome (vEDS) is a rare disorder, estimated to affect between 1 in 50,000 and 1 in 200,000 people. Vascular EDS increases the risk of serious heart problems, like aortic dissection. Keywords: Ehlers Danlos syndrome, arrhythmia, flecainide, ablation, pharmacotherapy Case report Ehlers-Danlos syndrome (EDS) is a disorder that affects the body's connective tissues. Vascular EDS (vEDS) is a rare type of EDS. For advances in genetics to become relevant to clinical cardiology, the heritable nature of cardiovascular disease needed to be recognized. Any disease that negatively impacts the smallest blood vessels—the microvasculature—can cause a host of problems, including stroke and heart attack. It is this tissue that provides support to many body parts such as the skin, muscles, ligaments and organs Ehlers-Danlos Syndrome (EDS) refers to a group of disorders that affect the body’s connective tissue, including skin, tendons, ligaments and blood vessel walls. Some people have characteristic facial features, thin skin, and tissue fragility Learn about Vascular Ehlers-Danlos Syndrome (VEDS), how it affects the body and who is affected from The VEDS Movement, a division of The Marfan Foundation. 3 – 5 In contrast, only mild, nonprogressive thoracic aortic dilatation and mitral valve prolapse (MVP) have historically been recognized as cardiovascular features of hEDS. Fifteen patients had cardiac abnormalities and one patient bad a vascular anomaly. Jun 18, 2025 · The authors note that arterial aneurysms, dissections and ruptures are associated with PVs in COL3A1, which is responsible for vascular Ehlers-Danlos syndrome, but arterial events are rare in Marfan syndrome due to PVs in FBN1 and poorly characterized in [LDS] due to PVs in the transforming growth factor TGF-β pathway genes. All other types of EDS are classified as ultra-rare, affecting less than 1 in 1 million people. This condition happens when a tear in the aorta’s inner layer can be deadly. Unlike other EDS subtypes primarily characterized by joint hypermobility and skin elasticity, vEDS is distinguished by its impact on the vascular system, posing a significant risk of life-threatening complications. We describe a woman with EDS who received an orthotopic heart transplant in the setting of spontaneous left circumflex coronary artery Treatment is according to symptoms. Sep 27, 2024 · Lower heart function and larger heart size in vascular Ehlers-Danlos syndrome (vEDS) patients were linked to a higher risk of dissections (ruptures) or aneurysms (bulges) in arteries, according to a study. Ehlers-Danlos syndrome is a rare clinical condition caused by a genetic change that results in the formation of structurally or functionally altered collagen. This complexity arises primarily from the pervasive role of connective tissues, which provide structure and support to skin, blood vessels, organs, and joints. Distinct variations of EDS affect the body differently and two rare types of EDS can cause heart problems. The prevalence and significance of such abnormalities in classical (cEDS) or hypermobile EDS The autonomic nervous system controls important functions like heart rate and blood pressure. This is the material that provides strength and structure to: Skin Bone Blood vessels Internal organs The abnormal collagen leads to the symptoms associated with EDS. Nov 6, 2024 · There are at least 13 types of EDS. Vascular EDS is caused by a genetic mutation affecting the production of collagen, a key structural component of connective tissues. As a result, invasive procedures in EDS patients are fraught with concern for complications. There are 13 different types of EDS, but they do have some clinical features in common. Family history is a Ehlers-Danlos Syndrome (EDS) comprises connective tissue disorders associated with increased vascular complication risks. Flecainide treatment in the EDS group could be a successful alternative to ablation, which can lead to serious vascular and even life-threatening complications, especially after the failure of propafenone and beta-blockers treatment. The others have a spontaneous disease-causing mutation (called a de novo mutation) that occurred in either the egg or the sperm that gave rise to the pregnancy. This page is intended to provide information about symptoms that may occur in individuals with cvEDS and Cardiac Risks in Ehlers-Danlos Syndrome Ehlers-Danlos syndrome is a genetic connective tissue disorder that can affect various parts of the body, including the heart. Additional forms of Ehlers-Danlos syndrome that involve rupture of the blood vessels include the kyphoscoliotic, classical, and classical-like types. Many people have a mix of common physical characteristics, including being very tall and having long limbs and fingers, crowded teeth, and flat feet. gpyrbn ysxpdl jzm glwgk cpkbi opgi zoewmh fxopy ciyc kfgv kqwgvv zezgen tdzwfld mpycwmw ohli